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Phosphoramidites

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General structures for Phosphoramidites


A phosphoramidite (RO)2PNR2 is a monoamide of a phosphite diester. The key feature of phosphoramidites is their markedly high reactivity towards nucleophiles catalyzed by weak acids e.c., triethylammonium chloride or 1H-tetrazole. In these reactions, the incoming nucleophile replaces the NR2 moiety.
Our nucleoside phosphoramidites are produced and packaged to ensure the highest performance on commercial oliognucleotide synthesizers. Every batch is accompanied by COA and Spec., showing the results of our QC testing.
  • Normal/modified Phosphoramidite

    B = Base (A, C, G, U, pU, I, T, abasic)
    P = Null, Me, NH2, Ac, Bz, dmf, iBu, PhAc, Pac, Tac, etc.
    X = H, F, OTBDMS, OMe, OMOE, O-Propargyl, etc.

  • 2'-O-4'-C-Locked Phosphoramidite

    B = Base (A, C, G, U, T)
    P = Null, Ac, Bz, dmf, iBu, PhAc, Pac, Tac, etc.

  • Reverse Phosphoramidite

    B = Base (A, C, G, U, T, abasic)
    P = Null, Ac, Bz, dmf, iBu, PhAc, Pac, Tac, etc.
    X = H, F, OMe, OMOE, OTBDMS, etc.

  • FANA Phosphoramidite

    B = Base (A, C, G, U)
    P = Null, Ac, Bz, iBu, etc

  • PMO Phosphoramidite

    B = Base (A, C, G, T)
    P = Null, Bz, Ac, iBu, dmf, PhAc, Pac, Tac, etc.

  • 3'-TrNH Phosphoramidites

    B = Base (A, C, G, T)
    P = Null, Ac, Bz, dmf, iBu, etc.

  • Linker Phosphoramidites

    P = DMT, MMT, Tr, TFA, etc.

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